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Condition

Colorectal Neoplasms, Hereditary Nonpolyposis

Oncology

Overview

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

This information is general and should not be treated as medical advice. Always speak directly with a qualified healthcare professional before making decisions about treatment, diagnosis, procedures, medicines or care.

Quick facts about Colorectal Neoplasms, Hereditary Nonpolyposis

Topic type
Condition
Category
Oncology
MeSH classification
C04.588.274.476.411.307.190|C04.700.250|C06.301.371.411.307.190|C06.405.249.411.307.190|C06.405.469.158.356.190|C06.405.469.491.307.190|C16.320.700.250|C18.452.284.255

Preparing for an appointment about Colorectal Neoplasms, Hereditary Nonpolyposis

If you are speaking with a healthcare professional about Colorectal Neoplasms, Hereditary Nonpolyposis, it can help to prepare a few details in advance.

  • Write down your symptoms and when they started.
  • Bring details of any medicines, supplements or previous treatments.
  • Ask what tests or assessments may be needed.
  • Ask what treatment or management options may be suitable.
  • Ask when you should seek urgent medical help or follow-up care.

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Source: Medical Subject Headings (MeSH), produced by the U.S. National Library of Medicine. EuroCareFinder is not endorsed by the National Library of Medicine. MeSH version: 2026.