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Diagnostic Test

Negative Staining

Diagnostics

Overview

The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.

This information is general and should not be treated as medical advice. Always speak directly with a qualified healthcare professional before making decisions about treatment, diagnosis, procedures, medicines or care.

Quick facts about Negative Staining

Topic type
Diagnostic Test
Category
Diagnostics
MeSH classification
E01.370.225.500.620.670.520|E01.370.225.750.600.670.520|E05.200.500.620.670.520|E05.200.750.600.670.520

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Source: Medical Subject Headings (MeSH), produced by the U.S. National Library of Medicine. EuroCareFinder is not endorsed by the National Library of Medicine. MeSH version: 2026.